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Rena Sofer is known for her appearances in daytime television, episodic guest appearances, and made-for-television movies
In 1995, Sofer received a Daytime Emmy Award for her portrayal of Lois Cerullo in the soap opera General Hospital. She reprised the role of Lois in October 2023. From 2013 to 2022, she played Quinn Fuller on the CBS soap opera The Bold and the Beautiful.